Professor Shanahan was educated in Australia and obtained a PhD in Genetics from the University of Adelaide. She began research in the field of cardiovascular medicine in the Biochemistry Department at the University of Cambridge UK. From 1995-2004 she was a British Heart Foundation Lecturer and in 2005 became a BHF Senior Fellow in the Department of Medicine, University of Cambridge. In 2007 she left Cambridge to take up the Chair of Cellular Signalling in the Cardiovascular Division at King’s College London.
Professor Shanahan’s work focuses on mechanisms of vascular smooth muscle cell (VSMC) dysfunction in ageing and disease. She has an international reputation in the field of vascular calcification and currently her work focuses on the role of nuclear envelope LINC complex proteins in driving premature vascular ageing and calcification. Using both cellular and preclinical models processes such as mechano-signalling, epigenetics and the DNA damage response are interrogated.
She is on the editorial boards of Circulation Research and ATVB and has served on the BHF Fellowships and Project Grants Committees.