Patrick Lacolley is specialized in cardiology and entered Inserm in 1987. He rapidly developed a particular interest for cellular and molecular determinants of arterial stiffness in hypertension, ageing and heart failure.
Since January 2005, he is director of the Inserm UMR_S 1116 which is devoted to the “Cardiovascular risk: stiffness-fibrosis and hypercoagulability”, with expertise in molecular and cell biology and experimental animal models. The major findings concern (1) vascular smooth muscle cells as major determinants of arterial stiffness; (2) the role of the renin angiotensin aldosterone system and cell matrix interactions in vascular remodeling; (3) cross-links, integrins and oxidative stress are involved in age-related alterations of vascular wall; and (4) vascular smooth muscle cells require pulsatility to interfere with the coagulation process.
Inserm UMR_S 1116
Université de Lorraine – Faculté de Médecine
9 avenue de la forêt de Haye
54505 Vandoeuvre les Nancy Cedex
00 33 (0) 3 72 74 62 43
00 33 (0) 6 86 85 51 63