Study Design

This is a longitudinal, multicentre study. The study will recruit individuals with recently confirmed infection by SARS-Cov-2, who will undergo 2 visits, 3-6 months and 1 year after COVID-19 diagnosis. During the visit, assessment of carotid-femoral PWV and central haemodynamics will be performed. Ancillary studies will explore additional biomarkers of accelerated vascular ageing (carotid geometry and stiffness, endothelial function, 24-h central blood pressure, small artery remodelling). Standard-operating procedure will be provided to all centers.

Moreover, a long-term (5 and 10-year) clinical follow-up will be planned, to evaluate the risk of CV events related to arterial stiffness and central haemodynamics in COVID-19 survivors.

Data collection will be centralised on an central electronic REDCap database, hosted by INSERM U970 (Paris, France). A user account with the appropriate user rights will be provided by the Principal Investigators once approval from the ethical committee is obtained. Any paper CRF must be transferred to the central REDCap database.

Disease-related information will be collected according to the standards of the WHO-ISARIC initiative for the patients who had been hospitalized for COVID-19 (https://ncov.medsci.ox.ac.uk.)